For Research Use Only. Not for Human Use.
CJC-1295 with DAC (Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Lys(Maleimidopropionyl)-NH₂) is a modified analog of growth hormone-releasing hormone (GHRH 1-29) featuring a Drug Affinity Complex (DAC) attached via a lysine linker at position 30, enabling strong binding to serum albumin for an extended half-life of 5–8 days. This allows sustained, pulsatile GH secretion without the rapid degradation of native GHRH, making it a subject of interest in neuroendocrine research. Developed by ConjuChem Biotechnologies in the mid-2000s, it advanced to Phase II clinical trials before discontinuation due to manufacturing issues. This research-grade lyophilized powder is synthesized under strict quality controls and includes full analytical documentation, making it suitable for in vitro and preclinical research applications.
Key Scientific Attributes
- High-purity CJC-1295 with DAC (≥99% by HPLC/MS, acetate salt form)
- Verified 30-amino-acid sequence with DAC modification for albumin bioconjugation
- Lyophilized formulation for enhanced long-term stability (up to 3 years at -4°F)
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and endotoxin testing (<0.001 EU/mg)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Suitable for receptor-binding, pharmacokinetic, and pituitary signaling studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Retains native pulsatile GH secretion profile relative to unmodified GHRH analogs in preclinical models
- Subject of preclinical investigations into neuroendocrine signaling and pituitary axis dynamics
- Pharmacokinetic profile characterized by extended albumin binding and reduced clearance rate
- Relevant to in vitro and preclinical studies of endocrine pathway modeling
Why Researchers Choose CJC-1295 with DAC
- Exact clinical-sequence match with DAC modification for authentic pharmacokinetics
- Third-party verified purity (>99%) and no fillers (e.g., mannitol-free)
- Transparent documentation (HPLC/MS COA, endotoxin-free)
- Suitable for use in endocrinology, neuroendocrine, and pituitary biology research settings
- Competitive research pricing with bulk options
This product is strictly for laboratory and research purposes only. Not for human or animal use. Not intended to diagnose, treat, cure, or prevent any condition.
