SS-31 is a water-soluble, cell-permeable mitochondria-targeting tetrapeptide developed by Stealth BioTherapeutics. It selectively concentrates >1,000-fold in the inner mitochondrial membrane where it binds cardiolipin, stabilizing cristae architecture, optimizing electron transport chain function, and preventing cytochrome c release. Currently in Phase 3 for primary mitochondrial myopathy and Barth syndrome, with completed trials in heart failure, renal ischemia, and neurodegeneration. This research-grade lyophilized peptide is synthesized under strict quality controls and provided with full analytical documentation, making it the gold-standard tool for mitochondrial medicine research.
Key Scientific Features
- High-purity SS-31 (≥ 99% by HPLC/MS, TFA salt form)
- Verified aromatic-cationic sequence: D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH₂
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for cardiolipin interaction, mitochondrial ROS, and bioenergetics studies
Research-Referenced Attributes (Based on scientific literature & clinical trials; not therapeutic claims.)
- Concentrates >1,000-fold in mitochondria → stabilizes cardiolipin and ETC supercomplexes
- Reduces mitochondrial ROS by 50–70% and prevents mPTP opening in ischemia-reperfusion
- Phase 2 heart failure (EMBRACE): improved cardiac energetics and exercise tolerance
- Neuroprotection in Parkinson’s, Alzheimer’s, and ALS models (preserves dopamine neurons)
- Renal protection: reduced AKI severity in multiple preclinical and Phase 2 trials
- Improves skeletal muscle function in primary mitochondrial myopathy (Phase 3 MMPOWER)
Why Researchers Choose Nationwide Peptides SS-31
- Exact clinical-sequence match to Stealth BioTherapeutics’ Elamipretide
- Highest documented mitochondrial uptake among research suppliers
- Transparent analytical data (HPLC >99%, MS confirmation)
- Trusted by mitochondrial medicine, cardiology, and neurology laboratories
- Competitive research pricing with bulk options
