SLU-PP-332 is a non-peptide, orally bioavailable pan-ERR agonist developed by researchers at Saint Louis University and the University of Florida. It strongly activates ERRα (EC₅₀ ≈ 98 nM) with activity at ERRβ/γ, inducing transcriptional programs for aerobic metabolism without affecting estrogen receptors. Known as an “exercise mimetic,” it replicates endurance training benefits in sedentary models by boosting energy expenditure and fat utilization. This research-grade crystalline compound is produced under strict quality controls and provided with full analytical documentation, ideal for metabolic, mitochondrial, and longevity research.
Key Scientific
- High-purity SLU-PP-332 (≥ 99% by HPLC/MS, free base or salt form)
- Verified structure: (E)-4-Hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide
- Crystalline powder for excellent stability and oral bioavailability
- Full Certificate of Analysis (COA) with HPLC, MS, NMR, and ERR activation assay (EC₅₀ confirmation)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for AMPK/PGC-1α induction, mitochondrial function, and exercise-mimetic studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Potent pan-ERR agonist (EC₅₀ 98 nM ERRα, 230 nM ERRβ, 430 nM ERRγ) → activates aerobic exercise gene program
- In obese mice: ↑ energy expenditure, ↑ fatty acid oxidation, ↓ fat mass (12–36% weight loss), improved insulin sensitivity
- “Exercise in a pill”: sedentary mice run 40–50% farther and longer after 4 weeks treatment
- Enhances mitochondrial respiration and biogenesis in skeletal muscle cells
- Potential in obesity, T2D, sarcopenia, NAFLD, and age-related metabolic decline
- Orally active; no estrogenic or hormonal disruption
Why Researchers Choose Nationwide Peptides SLU-PP-332
- Exact sequence match to landmark exercise-mimetic studies
- Highest documented ERR potency and oral bioavailability among suppliers
- Transparent analytical data (HPLC >99%, NMR confirmation)
- Trusted by exercise physiology, metabolism, and mitochondrial research laboratories
- Competitive research pricing with bulk options
