Sermorelin (Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂) is the bioactive N-terminal fragment of the 44-amino-acid natural GHRH. It selectively binds pituitary GHRH receptors to stimulate physiological, pulsatile GH secretion while preserving natural feedback loops — unlike exogenous hGH, which suppresses endogenous production. Once FDA-approved (1997–2008) for pediatric GH deficiency diagnostics and treatment, it remains the gold-standard research tool for adult GH axis studies. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity Sermorelin (≥ 98% by HPLC/MS, acetate salt form)
- Exact 29-amino-acid GRF 1-29 sequence (identical to human GHRH 1-29)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for pulsatile GH release, diagnostic challenge testing, and aging/neuroendocrine research
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Restores physiological pulsatile GH secretion in aging and GH-deficient models
- Increases IGF-1 levels in a dose-dependent, feedback-regulated manner
- Preserves natural GH negative feedback (unlike direct hGH) — no suppression of endogenous axis
- Enhances deep sleep (slow-wave), lean body mass, and fat oxidation in preclinical and historical human studies
- Improves bone density, immune function, and recovery parameters
- Synergistic with GHRP peptides (Ipamorelin, GHRP-2/6) for amplified GH pulses
- Valuable in diagnostic testing of pituitary reserve and age-related GH decline research
Why Researchers Choose Nationwide Peptides Sermorelin
- Exact clinical-sequence match (GRF 1-29, amidated C-terminus)
- Highest purity and bioactivity among research suppliers
- Transparent analytical data (HPLC >98%, MS confirmation)
- Trusted by endocrinology, aging, and diagnostic laboratories worldwide
- Competitive research pricing with bulk options
