PT-141 (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) is a cyclic, lactam-bridged analog of α-melanocyte-stimulating hormone (α-MSH) originally developed by Palatin Technologies as a tanning peptide. Unlike PDE5 inhibitors (Viagra®), it acts centrally via melanocortin-4 receptor (MC4R) activation in the hypothalamus to trigger sexual arousal and desire in both males and females. FDA-approved in 2019 as Vyleesi® for hypoactive sexual desire disorder (HSDD) in premenopausal women, it remains the only clinically validated peptide for female sexual dysfunction. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity PT-141 (≥ 98% by HPLC/MS, acetate salt form)
- Verified cyclic heptapeptide sequence with lactam bridge (Asp-Lys)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for sexual behavior, MC4R signaling, and arousal pathway research
Research-Referenced Attributes (Based on scientific literature & clinical trials; not therapeutic claims.)
- Central activation of MC4R → robust sexual arousal in both sexes (onset 30–90 min, duration 6–72 hours)
- Phase 3 trials (RECONNECT): 1.75 mg subcutaneous → 25–35% increase in satisfying sexual eventsand FSFI desire score in women with HSDD
- Male trials: spontaneous erections in 68–85% of doses vs. 19% placebo (p<0.01)
- No significant blood pressure effects compared to earlier Melanotan-II
- Potential applications in erectile dysfunction, female sexual arousal disorder, and obesity models
- Nasal and subcutaneous bioavailability; crosses blood-brain barrier
Why Researchers Choose Nationwide Peptides PT-141
- Exact clinical-sequence match to FDA-approved Bremelanotide (Vyleesi®)
- Highest documented MC4R affinity among research suppliers
- Transparent analytical data (HPLC >98%, MS confirmation of cyclic structure)
- Trusted by neuroendocrinology, sexual medicine, and pharmacology laboratories
- Competitive research pricing with bulk options
