PNC-27 is a synthetic anti-cancer peptide developed in the early 2000s by researchers at SUNY Downstate and NYU, combining the HDM-2-binding domain of p53 (residues 12-26) with a cell-penetrating/membrane residency peptide (MRP). It selectively binds HDM-2 expressed on cancer cell membranes, inducing transmembrane pore formation and rapid tumor cell necrosis without affecting normal cells. Preclinical studies show efficacy against pancreatic, breast, ovarian, leukemia, and other lines, with no toxicity in normal cells. This research-grade lyophilized peptide is synthesized under strict quality controls and provided with full analytical documentation, ideal for oncology and membrane biology research.
Key Scientific
- High-purity PNC-27 (≥ 98% by HPLC/MS, acetate salt form)
- Verified 32-amino-acid sequence with p53(12-26)-MRP fusion
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and in vitro necrosis assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for HDM-2 membrane targeting, pore formation, and selective cancer cell lysis studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Binds membrane HDM-2 in cancer cells → induces transmembrane pores and rapid necrosis (LDH release within hours)
- Kills p53-null, mutant, and wild-type cancer lines (pancreatic, breast, ovarian, leukemia) without harming normal cells
- Co-localizes with HDM-2 in cancer cell membranes but not untransformed cells
- In vivo: eradicates tumors in nude mice (pancreatic, melanoma) with no off-target toxicity
- Potential synergy with chemotherapy (e.g., paclitaxel in ovarian cancer)
- Valuable in solid/hematological tumor models, membrane oncology, and selective cytotoxicity research
Why Researchers Choose Nationwide Peptides PNC-27
- Exact sequence match used in original SUNY/NYU anti-cancer studies
- Highest documented selective necrosis potency among research suppliers
- Transparent analytical data (HPLC >98%, MS confirmation)
- Trusted by oncology, membrane biology, and pharmacology laboratories
- Competitive research pricing with bulk options