MOTS-c is a revolutionary mitochondrial-encoded peptide discovered in 2015 by Pinchas Cohen’s group at USC. Encoded within the 12S rRNA region of mtDNA, it translocates to the nucleus under metabolic stress to regulate genes involved in energy homeostasis, glucose metabolism, and inflammation. Systemic administration mimics key benefits of exercise — increasing AMPK phosphorylation, GLUT4 translocation, fatty acid oxidation, and insulin sensitivity while reducing obesity and inflammatory markers. This research-grade lyophilized peptide is synthesized under strict quality controls and provided with full analytical documentation, making it the gold-standard for mitochondrial signaling, exercise physiology, and metabolic disease research.
Key Scientific
- High-purity MOTS-c (≥ 99% by HPLC/MS, acetate salt form)
- Verified 16-amino-acid sequence: Met-Arg-Trp-Leu-Ser-Leu-Leu-Arg-Ser-Pro-Pro-Gly-Leu-Ala-Trp-Leu-Arg-Leu-Phe-Gly
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and bioactivity assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for AMPK activation, mitochondrial retrograde signaling, and exercise-mimetic studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- “Exercise in a peptide”: single 15 mg/kg dose in mice → AMPK activation equivalent to 3 weeks of endurance training
- Prevents diet-induced obesity and insulin resistance (HFD mice lose 15–20% body weight)
- Improves glucose uptake and insulin sensitivity in skeletal muscle via GLUT4 translocation
- Reduces inflammatory cytokines (IL-6, TNF-α) and protects against age-related metabolic decline
- Extends healthspan and lifespan in mouse models of accelerated aging
- Valuable in T2D, obesity, sarcopenia, NAFLD, and mitochondrial disease research
Why Researchers Choose Nationwide Peptides MOTS-c
- Exact human mitochondrial-encoded sequence used in all landmark studies
- Highest documented AMPK activation and exercise-mimetic potency among suppliers
- Transparent analytical data (HPLC >99%, MS confirmation)
- Trusted by mitochondrial biology, metabolism, and longevity laboratories worldwide
- Competitive research pricing with bulk options
