Kisspeptin-10 is the shortest biologically active fragment of the KISS1 gene product that fully retains potency at the kisspeptin receptor (KISS1R/GPR54). First identified in 2001 as the endogenous ligand driving pubertal onset, it is now recognized as the master upstream regulator of pulsatile GnRH secretion. Intravenous or subcutaneous administration produces rapid, dose-dependent LH surges (5–20× baseline within 30 min) in humans and animals, making it the gold-standard tool for fertility, hypogonadism, and reproductive neuroendocrinology research. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity Kisspeptin-10 (≥ 99% by HPLC/MS, acetate or TFA salt form)
- Verified native decapeptide sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for GnRH neuron activation, LH/FSH pulsatility, and fertility cycle research
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Most potent natural trigger of GnRH release → LH surge 5–20× baseline in men & women
- Restores HPG axis in hypogonadotropic hypogonadism (HH) and functional hypothalamic amenorrhea (FHA) models
- Induces ovulation in IVF protocols (Phase 2/3 trials ongoing)
- Increases testosterone within 2–4 hours in males; mimics natural LH pulse frequency
- Regulates puberty onset and circadian reproductive rhythms via KISS1R on GnRH neurons
- Valuable in infertility, delayed puberty, PCOS, contraception, and hormone replacement research.
Why Researchers Choose Nationwide Peptides Kisspeptin-10
- Exact human active core sequence used in all major clinical fertility trials
- Highest documented LH-inducing potency among kisspeptin fragments
- Transparent analytical data (HPLC >99%, MS confirmation)
- Trusted by reproductive endocrinology, fertility, and neuroendocrinology laboratories
- Competitive research pricing with bulk options
