IGF-1 LR3 is the most widely used long-acting IGF-1 analog in research. The two key modifications — Arg³ substitution and the MFPAMPLSSLFVNG N-terminal extension — dramatically reduce binding to IGF-binding proteins (IGFBPs), extending plasma half-life from ~10 minutes (native IGF-1) to 20–30 hours while increasing potency 3–10× at the IGF-1 receptor. This allows sustained anabolic signaling without the rapid clearance of natural IGF-1. First described in the 1990s, it remains the gold-standard for studies requiring prolonged IGF-1 exposure. This research-grade lyophilized powder is produced under strict quality controls and provided with full analytical documentation.
Key Scientific Features
- High-purity IGF-1 LR3 (≥ 98% by HPLC/MS, receptor-grade)
- Verified 83-amino-acid sequence with Arg³ + 13-aa extension (MFPAMPLSSLFVNG)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and bioactivity assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for muscle hypertrophy, satellite cell proliferation, and IGF-1R signaling studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- 100–120× longer half-life than native IGF-1 → sustained IGF-1R activation
- 3–10× greater potency than IGF-1R binding and downstream Akt/mTOR signaling
- Promotes muscle hyperplasia and hypertrophy (new fiber formation + fiber growth)
- Enhances glucose/fatty acid uptake and inhibits myostatin in preclinical models
- Neuroprotective in brain injury models via BDNF upregulation
- Valuable in sarcopenia, muscular dystrophy, wound healing, and performance physiology research
Why Researchers Choose Nationwide Peptides IGF-1 LR3
- Exact receptor-grade sequence used in original longevity & hypertrophy studies
- Highest documented potency and half-life among research suppliers
- Transparent analytical data (HPLC >98%, MS confirmation of full sequence)
- Trusted by muscle physiology, regenerative medicine, and endocrinology laboratories worldwide
- Competitive research pricing with bulk options