Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ · acetate) is the synthetic form of natural gonadotropin-releasing hormone (GnRH) produced in the hypothalamus. It binds pituitary GnRH receptors to trigger pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), initiating downstream testosterone or estradiol production. FDA-approved since 1978 (Factrel®, Lutrepulse®) for diagnostic testing of pituitary function and treatment of hypogonadotropic hypogonadism, it remains the gold-standard research tool for HPG axis, fertility, and pulsatile hormone studies. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific Features
- High-purity Gonadorelin Acetate (≥ 99% by HPLC/MS, acetate salt form)
- Verified native decapeptide sequence (amidated C-terminus, pyroglutamic N-terminus)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and endotoxin testing (<0.001 EU/mg)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for pituitary challenge testing, pulsatile LH/FSH studies, and fertility research
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Rapid, dose-dependent LH/FSH release (peak within 15–30 min) for diagnostic evaluation of pituitary reserve
- Restores pulsatile gonadotropin secretion in hypogonadotropic models when delivered in pulsatile fashion
- Increases testosterone/estradiol via downstream Leydig/Sertoli or ovarian stimulation
- No tachyphylaxis with physiological pulsatile administration; continuous exposure causes downregulation (basis for GnRH agonist therapy)
- Valuable in infertility, delayed puberty, cryptorchidism, and HPG axis disruption research
- High nasal bioavailability in some species; standard for pulsatile pump studies
Why Researchers Choose Nationwide Peptides Gonadorelin Acetate
- Exact FDA-approved clinical sequence (Factrel®/Lutrepulse® match)
- Highest purity (>99%) and lowest endotoxin levels among research suppliers
- Transparent analytical data (HPLC/MS COA, endotoxin-free)
- Trusted by reproductive endocrinology, fertility, and neuroendocrinology laboratories
- Competitive research pricing with bulk options
