FOXO4-DRI is a groundbreaking D-amino acid retro-inverso peptide developed by Peter de Keizer’s group at Erasmus MC. It selectively disrupts the FOXO4-p53 interaction that protects senescent cells from apoptosis, inducing their targeted clearance while sparing healthy cells. First published in 2017, it demonstrated dramatic lifespan extension and tissue rejuvenation in progeroid and naturally aged mice. This research-grade lyophilized peptide is synthesized under strict quality controls and provided with full analytical documentation, making it the gold-standard tool for senolytics, longevity, and age-related disease research.
Key Scientific
- High-purity FOXO4-DRI (≥ 99% by HPLC/MS, TFA salt form)
- Verified D-retro-inverso octapeptide sequence: D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and in vitro p53-binding disruption assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for senescent cell clearance, FOXO4-p53 interaction, and anti-aging studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Selectively disrupts FOXO4-p53 nuclear retention → targeted apoptosis of senescent cells (senolytics)
- Dramatically extends lifespan in progeroid mice (up to 30%) and rejuvenates tissues in naturally aged animals
- Reduces senescent cell burden in liver, kidney, and muscle without affecting healthy cells
- Improves physical function, fur density, and wound healing in aged mice
- No genotoxicity or off-target effects in preclinical safety studies
- Valuable in progeria, sarcopenia, fibrosis, and age-related degenerative disease research
Why Researchers Choose Nationwide Peptides FOXO4-DRI
- Exact D-retro-inverso sequence used in the original Erasmus MC discovery studies
- Highest documented senolytic potency and selectivity among research suppliers
- Transparent analytical data (HPLC >99%, MS confirmation of D-amino acids)
- Trusted by longevity, senolytics, and regenerative medicine laboratories worldwide
- Competitive research pricing with bulk options
