Follistatin 344 is the predominant circulating isoform of follistatin, a naturally occurring glycoprotein that binds and neutralizes myostatin (GDF-8), activin A, and other TGF-β family members to remove inhibition of muscle growth. First identified in ovarian follicular fluid as an activin antagonist, it is now the most powerful endogenous inhibitor of myostatin — making it the gold-standard tool for muscle hyperplasia research. Recombinant FS-344 (with N-terminal domain removed for higher systemic stability) has been studied in primates and humans (Phase 1/2 for Becker muscular dystrophy) showing dramatic muscle mass increases. This research-grade lyophilized protein is produced under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity Follistatin 344 (≥ 98% by HPLC/SDS-PAGE, recombinant human sequence)
- Verified 344-amino-acid mature isoform (Gly30–Asp344) with correct disulfide bonding
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, SDS-PAGE, myostatin/activin binding ELISA, and endotoxin testing
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for myostatin blockade, muscle hyperplasia, and TGF-β antagonism studies
Research-Referenced Attributes (Based on scientific literature & clinical trials; not therapeutic claims.)
- Most potent myostatin inhibitor known → up to +200% muscle mass in transgenic mice
- Phase 1/2 trial (Becker MD): single IV dose → +10–15% lean mass and functional gains at 6 months
- Increases satellite cell proliferation and fusion → true muscle hyperplasia (new fibers)
- Improves bone density, tendon strength, and fat metabolism secondary to muscle growth
- Neutralizes activin A → potential in cancer cachexia and reproductive research
- Valuable in Duchenne/Becker MD, sarcopenia, cachexia, and performance physiology models
Why Researchers Choose Nationwide Peptides Follistatin 344
- Exact clinical-sequence match to Acceleron/Wyler’s Phase 2 candidate
- Highest documented myostatin-neutralizing titer among research suppliers
- Transparent analytical data (HPLC/SDS-PAGE + functional myostatin binding assay)
- Trusted by muscle physiology, neuromuscular disease, and regenerative medicine laboratories
- Competitive research pricing with bulk options
