Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic

DSIP (Delta Sleep-Inducing Peptide)
DSIP (Delta Sleep-Inducing Peptide)
$49.00 – $113.00Price range: $49.00 through $113.00 Select options
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DSIP (Delta Sleep-Inducing Peptide)

Price range: $49.00 through $113.00

Research-grade DSIP (Delta Sleep-Inducing Peptide), a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), designed for controlled investigations of sleep architecture, stress hormone modulation, neuroprotection, and circadian rhythm regulation.

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DSIP was first isolated from cerebral venous blood of sleep-deprived rabbits in 1977 by the Swiss Schoenenberger-Monnier group. This amphiphilic nonapeptide crosses the blood-brain barrier freely and modulates sleep-wake cycles, reduces ACTH/cortisol responses to stress, and exhibits antioxidant and anticonvulsant properties. Although never brought to market as a pharmaceutical, it remains one of the most studied natural sleep peptides in Russia and Eastern Europe, where it has been used clinically for insomnia, withdrawal syndromes, and pain management. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation, ideal for sleep, stress, and neuroendocrine research.

Key Scientific

  • High-purity DSIP (≥ 98% by HPLC/MS, acetate salt form)
  • Verified nonapeptide sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
  • Lyophilized formulation for maximum long-term stability
  • Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
  • Manufactured in GMP-aligned, ISO-compliant facilities
  • Ideal for sleep induction, ACTH/cortisol suppression, and neuroprotection studies

Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)

  • Promotes delta-wave (slow-wave) sleep and normalizes sleep architecture in insomnia models
  • Reduces stress-induced ACTH and cortisol release; used in opioid/alcohol withdrawal studies
  • Exhibits analgesic, anticonvulsant, and antioxidant effects in rodent models
  • Modulates LH release and may influence dopamine/serotonin systems
  • Crosses BBB easily; active via intravenous, subcutaneous, intranasal, and oral routes
  • Potential applications in chronic pain, epilepsy, and PTSD-related sleep disturbance

Why Researchers Choose Nationwide Peptides DSIP

  • Exact native sequence match used in original Russian clinical studies
  • Highest documented sleep-promoting activity among research suppliers
  • Transparent analytical data (HPLC >98%, MS confirmation)
  • Trusted by sleep medicine, neuroendocrinology, and addiction research laboratories
  • Competitive research pricing with bulk options

Storage & Handling

  • Store lyophilized powder at –4 °F (long-term) or 39.2 °F (short-term)
  • Store in a tightly sealed container and protect from light, moisture, air exposure, and elevated temperatures.
  • Reconstitute only with bacteriostatic water or sterile saline (typical concentration 0.5–2 mg/mL)
  • Reconstituted solutions stable at 39.2 °F for up to 4 weeks; avoid repeated freeze-thaw cycles
  • Use appropriate PPE and aseptic technique

Peptide Research

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