CJC-1295 with DAC (Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Lys(Maleimidopropionyl)-NH₂) is a modified analog of growth hormone-releasing hormone (GHRH 1-29) featuring a drug affinity complex (DAC) attached via a lysine linker at position 30, enabling strong binding to serum albumin for an extended half-life of 5-8 days. This allows sustained, pulsatile GH secretion without the rapid degradation of native GHRH, making it a cornerstone for neuroendocrine research. Developed by ConjuChem Biotechnologies in the mid-2000s, it advanced to Phase II trials before discontinuation due to manufacturing issues. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation, ideal for metabolic, regenerative, and hormonal pathway studies.
Key Scientific
- High-purity CJC-1295 with DAC (≥ 99% by HPLC/MS, acetate salt form)
- Verified 30-amino-acid sequence with DAC modification for albumin bioconjugation
- Lyophilized formulation for enhanced long-term stability (up to 3 years at -20°C)
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and endotoxin testing (<0.001 EU/mg)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for sustained GH/IGF-1 elevation, receptor-binding, and pharmacokinetic studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Prolongs GH release (2-10x baseline for 6+ days) and IGF-1 elevation (1.5-3x for 9-11 days) via albumin bioconjugation
- Preserves natural pulsatile GH secretion while enhancing bioavailability over native GHRH
- Supports muscle protein synthesis, fat oxidation, and bone density in preclinical models
- Minimal impact on cortisol, prolactin, or ACTH compared to other secretagogues
- Valuable in aging, sarcopenia, cachexia, and tissue regeneration research
- Synergistic with GHRPs (e.g., Ipamorelin) for amplified GH pulses (3-5x greater effects)
Why Researchers Choose Nationwide Peptides CJC-1295 with DAC
- Exact clinical-sequence match with DAC modification for authentic pharmacokinetics
- Third-party verified purity (>99%) and no fillers (e.g., mannitol-free)
- Transparent documentation (HPLC/MS COA, endotoxin-free)
- Trusted by endocrinology, metabolic, and regenerative biology laboratories
- Competitive research pricing with bulk options
