Cagrilintide is an investigational long-acting amylin receptor agonist developed by Novo Nordisk as the first once-weekly amylin analog. It mimics the pancreatic hormone amylin to reduce food intake, delay gastric emptying, and enhance satiety via activation of calcitonin/amylin receptors in the area postrema and hypothalamus. When combined with GLP-1 agonists (e.g., semaglutide in CagriSema), it produces additive weight loss and superior glycemic control. Currently in Phase 3 (REDEFINE program) for obesity and diabetes, with Phase 2 data showing up to −15.6% body weight loss at 52 weeks (4.5 mg dose). This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity Cagrilintide (≥ 98% by HPLC/MS, acetate salt form)
- Verified 37-amino-acid sequence with C14 fatty diacid lipidation at Lys²
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, lipidation verification, and receptor-binding data
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for amylin receptor, energy homeostasis, and combination incretin research
Research-Referenced Attributes (Based on published clinical/preclinical literature; not therapeutic claims.)
- Once-weekly dosing with half-life ~200 hours (vs. pramlintide’s 45 minutes)
- Phase 2 monotherapy: −10.8% to −15.6% weight loss at 52 weeks (dose-dependent 0.3–4.5 mg)
- CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg): −22.7% weight loss at 68 weeks (vs. −15.6% semaglutide alone)
- Superior gastric emptying delay and satiety vs. GLP-1 alone
- Significant HbA1c reduction (−2.2%) and fasting glucose improvement
- Favorable lipid profile and blood pressure lowering
- Valuable in obesity, T2D, NAFLD, and combination incretin research
Why Researchers Choose Nationwide Peptides Cagrilintide
- Exact clinical-sequence match to NNC0174-0833 with correct C14 lipidation
- Highest documented AMYR affinity and half-life among research suppliers
- Transparent analytical data (HPLC >98%, MS confirmation of lipidated structure)
- Trusted by metabolic disease, obesity, and incretin pharmacology laboratories
- Competitive research pricing with bulk options

