AOD9604 is a modified, orally active analogue of the hGH C-terminal fragment (residues 177-191 with N-terminal tyrosine addition and disulfide cyclisation), first developed in the 1990s by Metabolic Pharmaceuticals for obesity treatment. It selectively stimulates lipolysis via upregulation of beta-3 adrenergic receptors without elevating IGF-1 or causing hGH-like anabolic side effects. Despite promising early rodent data, clinical trials showed modest efficacy (1.8 kg additional loss over 12 weeks), leading to development termination in 2007. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation, ideal for metabolic, obesity, and cartilage repair studies.
Key Scientific
- High-purity AOD9604 (≥ 98% by HPLC/MS, cyclized acetate salt form)
- Verified 16-amino-acid sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bridge between Cys7-Cys14)
- Lyophilized formulation for enhanced long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for lipolytic assays, beta-3 AR modulation, and osteoarthritis research
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Stimulates lipolysis and fat oxidation via beta-3 adrenergic receptor upregulation in adipose tissue
- Reduces body weight and improves lipid profiles in obese rodent models without IGF-1 elevation
- Potential cartilage repair and osteoporosis prevention through direct osteoblast stimulation
- No genotoxic, mutagenic, or diabetogenic effects observed in preclinical safety studies
- Oral bioavailability in animal models; well-absorbed with rapid degradation kinetics
- Valuable in metabolic syndrome, NAFLD, and performance enhancement research
Why Researchers Choose Nationwide Peptides AOD9604
- Exact clinical-sequence match with tyrosine addition and disulfide cyclization
- Consistent potency and oral activity batch-to-batch
- Transparent analytical data (HPLC >98%, MS confirmation)
- Trusted by metabolic endocrinology, obesity, and orthopedics laboratories
- Competitive research pricing with bulk options
