Alprostadil is the synthetic form of naturally occurring Prostaglandin E1 (PGE1), a potent vasodilator that relaxes smooth muscle via EP2/EP4 receptor activation and increases cAMP. First isolated in 1935 and synthesized in 1964, it is FDA-approved for erectile dysfunction (ED) as Caverject®/Edex® (intracavernosal) and for maintaining ductus arteriosus patency in neonates (Prostin VR®). This research-grade lyophilized or crystalline powder is produced under strict pharmaceutical standards and provided with full analytical documentation, ideal for vascular, urology, and neonatal research.
Key Scientific
- High-purity Alprostadil (≥ 99% by HPLC, pharmaceutical grade)
- Verified stereospecific structure: 11α,15S-dihydroxy-9-oxoprost-5Z,13E-dienoic acid
- Lyophilized or crystalline formulation for maximum stability
- Full Certificate of Analysis (COA) with HPLC, NMR, mass spectrometry, and bioactivity assay (cAMP elevation)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for vasodilation, smooth muscle relaxation, and prostaglandin signaling studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Potent vasodilator: relaxes corpus cavernosum smooth muscle → erectile response in 70–85% of ED patients (intracavernosal 5–20 mcg)
- Maintains PDA patency in neonates: 0.05–0.1 mcg/kg/min IV infusion → 95% success rate
- Improves peripheral circulation in PAD: 10–40 mcg intra-arterial → increased walking distance 50–100%
- Anti-inflammatory and anti-platelet effects via cAMP elevation
- Half-life ~5–10 minutes — ideal for acute signaling studies
- Valuable in ED, neonatal cardiology, peripheral artery disease, and inflammation research
Why Researchers Choose Nationwide Peptides Alprostadil
- Exact pharmaceutical-sequence match to FDA-approved Caverject®/Prostin VR®
- Highest documented potency (mcg/mL) among research suppliers
- Transparent analytical data (HPLC >99%, NMR stereochemistry confirmation)
- Trusted by urology, cardiology, neonatology, and vascular biology laboratories
- Competitive research pricing with bulk options
