AICAR (Acadesine, AICA-riboside) is an adenosine analog that enters cells and is phosphorylated to ZMP, mimicking AMP and directly activating AMPK — the master metabolic sensor. First studied in the 1990s for cardiac ischemia, it gained fame as an “exercise in a pill” after demonstrating endurance enhancement in sedentary mice equivalent to trained animals. Currently in Phase 3 for B-cell chronic lymphocytic leukemia (under orphan designation), it is the gold-standard pharmacological tool for AMPK research. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity AICAR (≥ 99% by HPLC/MS, free base or salt form)
- Verified structure: 5-Amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, NMR, and endotoxin testing
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for AMPK phosphorylation, PGC-1α induction, and metabolic reprogramming studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Direct, allosteric AMPK activation → ↑ glucose uptake (GLUT4 translocation) independent of insulin
- Induces mitochondrial biogenesis and fatty acid oxidation via PGC-1α in muscle cells
- “Exercise-mimetic” effect: sedentary mice given AICAR (500 mg/kg/day) matched endurance of trained controls
- Neuroprotective in ischemia models; cardioprotective via reduced infarct size
- Potential anti-cancer effects through mTOR inhibition and autophagy induction
- WADA-banned performance enhancer (metabolic modulator class)
Why Researchers Choose Nationwide Peptides AICAR
- Pharmaceutical-grade purity used in original exercise-mimetic studies
- Highest documented AMPK activation potency among research suppliers
- Transparent analytical data (HPLC >99%, MS/NMR confirmation)
- Trusted by exercise physiology, metabolism, and oncology laboratories worldwide
- Competitive research pricing with bulk options
