5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (IC₅₀ ≈ 1–5 µM), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA) and depleting intracellular NAD+ pools. By blocking NNMT, 5-Amino-1MQ dramatically increases NAD+ levels, activates SIRT1, enhances mitochondrial function, and shifts metabolism toward fat oxidation. First identified in 2017 as a breakthrough anti-obesity and anti-diabetic compound, it is currently in preclinical development for NASH, obesity, and multiple cancers. This research-grade crystalline powder is produced under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity 5-Amino-1MQ (≥ 99% by HPLC/MS, TFA or free-base form)
- Verified structure: 5-amino-1-methylquinolinium
- Crystalline powder for maximum long-term stability and oral bioavailability
- Full Certificate of Analysis (COA) with HPLC, MS, NMR, and NNMT inhibition assay (IC₅₀ confirmation)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for NNMT inhibition, NAD+ boosting, and metabolic reprogramming studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Potent NNMT inhibitor (IC₅₀ 1–5 µM) → ↑ cellular NAD+ 2–4× within hours
- 30–50% body fat reduction in diet-induced obese mice (DIO) mice at 20–40 mg/kg oral daily
- Reverses insulin resistance and improves glucose tolerance without affecting food intake
- Suppresses cancer cell proliferation (pancreatic, prostate, liver) via NAD+ depletion reversal and SIRT1 activation
- Increases muscle endurance and mitochondrial biogenesis via AMPK/PGC-1α upregulation
- Orally bioavailable; crosses blood-brain barrier — potential in neurodegeneration and aging research
Why Researchers Choose Nationwide Peptides 5-Amino-1MQ
- Exact sequence used in all landmark NNMT/obesity studies
- Highest documented potency and oral bioavailability among suppliers
- Transparent analytical data (HPLC >99%, NMR confirmation)
- Trusted by metabolic disease, oncology, and longevity laboratories worldwide
- Competitive research pricing with bulk options
