PEG-MGF is the long-acting, pegylated version of Mechano Growth Factor (MGF / IGF-1Ec). The covalent attachment of a 20–30 kDa linear or branched PEG chain to the N-terminus dramatically extends plasma half-life from minutes (native MGF) to several days while preserving full biological activity. This allows systemic delivery with sustained exposure, making it ideal for models requiring prolonged satellite cell proliferation and muscle regeneration without repeated local injections. First described in 2004–2006 as an improvement over native MGF, PEG-MGF is the preferred isoform for whole-body or neurological repair studies. This research-grade lyophilised peptide is synthesised under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity PEG-MGF (≥ 98% by HPLC/SEC, acetate salt form)
- Verified 24-amino-acid MGF sequence with site-specific 20–30 kDa PEG conjugation
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, SEC (size-exclusion), MALDI-TOF MS (PEG confirmation), and bioactivity assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for systemic satellite cell activation, extended-release repair, and neurological regeneration studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Half-life extended from minutes to 2–5 days via PEG shielding from proteases
- Systemic administration achieves 20–40% muscle cross-sectional area increase in rodent overload/injury models
- Superior to native MGF for whole-body or contralateral muscle repair (diffuses systemically)
- Neuroprotective in stroke, spinal cord injury, and ALS models via sustained satellite cell support
- Enhances bone regeneration and cardioprotection in preclinical studies
- Valuable in sarcopenia, muscular dystrophy, cachexia, and neurological injury research
Why Researchers Choose Nationwide Peptides PEG-MGF
- Exact research-grade sequence with verified 20–30 kDa linear PEG conjugation
- Highest documented systemic half-life and satellite cell activation among suppliers
- Transparent analytical data (SEC + MALDI-TOF for PEG confirmation)
- Trusted by muscle physiology, regenerative medicine, and neurology laboratories
- Competitive research pricing with bulk options
