IGF-1 DES (1-3) is the most potent and shortest-acting IGF-1 analog available for research. By removing the N-terminal tripeptide (Gly-Pro-Glu), it loses nearly all affinity for IGF-binding proteins (IGFBPs), resulting in a plasma half-life of only ~10–20 minutes — but dramatically increased potency (~10–20× native IGF-1) at the IGF-1 receptor. This makes it ideal for local intramuscular or subcutaneous injection to create highly site-specific anabolic effects without systemic spillover. First identified as a natural IGF-1 variant in brain and colostrum, it is now the preferred peptide for researchers studying localized muscle growth and hyperplasia. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific Features
- High-purity IGF-1 DES (1-3) (≥ 98% by HPLC/MS, receptor-grade)
- Verified 67-amino-acid truncated sequence (starting from position 4 of native IGF-1)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and bioactivity assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for site-specific muscle hyperplasia, satellite cell activation, and ultra-short-acting IGF-1R studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Virtually no IGFBP binding → 10–20× greater potency than native IGF-1 or IGF-1 LR3
- Ultra-short half-life (~10–20 min) → highly localized anabolic effects when injected near target muscle
- Induces true muscle hyperplasia (new fiber formation) via satellite cell activation
- 30–50% increase in muscle cross-sectional area at injection site in rodent models
- Minimal systemic exposure — ideal for unilateral hypertrophy studies
- Valuable in sarcopenia, muscular dystrophy, sports injury recovery, and localized repair research
Why Researchers Choose Nationwide Peptides IGF-1 DES
- Exact truncated sequence used in original site-specific hyperplasia studies
- Highest documented localized potency among IGF-1 analogs
- Transparent analytical data (HPLC >98%, MS confirmation of 67-aa length)
- Trusted by muscle physiology, regenerative medicine, and sports science laboratories
- Competitive research pricing with bulk options
