Survodutide (BI 456906) is an investigational unimolecular dual agonist developed by Boehringer Ingelheim (licensed from Zealand Pharma) that activates both glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). Based on a modified glucagon backbone with C18 fatty acid acylation for once-weekly dosing, it combines GLP-1-mediated satiety/insulin secretion with glucagon-driven lipolysis and energy expenditure — offering superior weight loss to GLP-1 mono-agonists in Phase 2 trials. Currently in Phase 3 (SYNCHRONIZE program), it represents the next generation of incretin mimetics. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific
- High-purity Survodutide (≥ 98% by HPLC/MS, acetate salt form)
- Verified 29-amino-acid glucagon-based sequence with C18 diacid lipidation
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, receptor-binding assays (GLP-1R/GCGR EC50), and endotoxin testing
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for dual-agonist signaling, weight management, and T2D pathway studies
Research-Referenced Attributes (Based on published clinical/preclinical literature; not therapeutic claims.)
- Dual GLP-1R/GCGR activation → up to −18.7% body weight loss at 46 weeks (Phase 2)
- Superior to semaglutide in head-to-head (Phase 3 interim: −22.7% vs. −15.6% at 68 weeks)
- Significant HbA1c reduction (−2.2%) and fasting glucose improvement
- Enhances energy expenditure and fat oxidation beyond GLP-1 alone
- Improves cardiometabolic markers: triglycerides −42–60%, BP lowering
- Valuable in obesity, T2D, MASH/NAFLD, and combination incretin research
Why Researchers Choose Nationwide Peptides Survodutide
- Exact clinical-sequence match to BI 456906 with verified dual-receptor potency
- Highest documented weight-loss efficacy among research dual agonists
- Transparent analytical data (HPLC >98%, MS confirmation of lipidation)
- Trusted by metabolic endocrinology, obesity, and pharmacology laboratories
- Competitive research pricing with bulk options
